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Clinical Trial
. 2004 Dec;6(12):682-9.
doi: 10.1111/j.1524-6175.2004.03707.x.

Different effects of losartan and moxonidine on endothelial function during sympathetic activation in essential hypertension

Michael N Doumas  1 , Stella N Douma, Kostas M Petidis, Kostas V Vogiatzis, Ilias C Bassagiannis, Chris X Zamboulis
Affiliations
Clinical Trial

Different effects of losartan and moxonidine on endothelial function during sympathetic activation in essential hypertension

Michael N Doumas et al. J Clin Hypertens (Greenwich). 2004 Dec.

Abstract

The aim of this study was to investigate: 1) the effects of treadmill exercise on plasma catecholamines and endothelin-1 (ET-1, a potent vasoconstrictor) levels in hypertensive patients; and 2) the impact of 1-month therapy with losartan as compared with moxonidine on catecholamine and ET-1 changes during exercise. Twenty-eight patients with essential hypertension were randomized in two groups: group A received losartan and group B received moxonidine for 1 month. Plasma catecholamines exhibited an almost 10-fold increase during exercise (p<0.00001) before treatment. Moxonidine significantly decreased catecholamine levels (p<0.05), while losartan reduction was nonsignificant (p<0.36). Plasma ET-1 increased significantly during exercise before treatment (p<0.00005). Moxonidine therapy did not affect ET-1 levels (p<0.88), while losartan resulted in a significant decrease of ET-1 levels both at baseline and during exercise (p<0.007). These findings suggest a mechanism for the reduced cardiovascular mortality noted with an angiotensin receptor blocker as compared with a sympatholytic agent.

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Figures

Figure 1
Figure 1
Systolic blood pressure changes during exercise before (pre) and after treatment with losartan (los) and moxonidine (mox)
Figure 2
Figure 2
Plasma noradrenaline (pg/mL) changes during exercise before (pre) and after treatment with losartan (los) and moxonidine (mox)
Figure 3
Figure 3
Plasma adrenaline (pg/mL) changes during exercise before (pre) and after treatment with losartan (los) and moxonidine (mox)
Figure 4
Figure 4
Plasma endothelin‐1 (pg/mL) changes during exercise before (pre) and after treatment with losartan (los) and moxonidine (mox)
See this image and copyright information in PMC

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