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Review
. 2005 Jan;99(1):64-70.
doi: 10.1016/j.tripleo.2004.07.002.

Oral alveolar soft-part sarcoma: review of literature and case report with immunohistochemistry study for prognostic markers

Kelen Christine do Nascimento Souza  1 , Paulo Rogério Faria, Ivan Miguel Costa, Antonio Francisco Duriguetto Jr, Adriano Mota Loyola
Affiliations
Review

Oral alveolar soft-part sarcoma: review of literature and case report with immunohistochemistry study for prognostic markers

Kelen Christine do Nascimento Souza et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Jan.

Abstract

Objective: To describe a case of alveolar soft-part sarcoma (ASPS) affecting the tongue of a child and to study prognostic imunohistochemical markers for the disease.

Study design: Tissue sections were incubated with primary antibodies reactive to neuron-specific enolase (NSE), vimentin, desmin, S-100 protein, cytokeratins AE1-AE3, EMA, neurofilament, synaptophysin, and muscle-specific actin (MSA), and for prognostic markers, including Ki-67, p53, bcl-2, bax, and nm23.

Results: Histologically, the tumor showed a proliferation of large polygonal cells with PAS-positive diastase-resistant intracytoplasmatic material, arranged in an alveolar growth pattern. Diffuse positive reaction for neuron specific enolase (NSE), focal reactivity for desmin and S-100 protein, strong positivity for nm23 and bax, but weak reaction for p53 and Ki-67 were found. No bcl-2-positive cells were noted.

Conclusion: These immunohistochemical findings may reflect the less aggressive behavior of ASPS in oral tissues.

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