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. 2004 Dec;15(12):951-9.
doi: 10.1007/s00335-004-3030-8.

Development of a highly fecund inbred strain of mice

Marte Holt  1 , Frank W Nicholas, John W James, Chris Moran, Ian C A Martin
Affiliations

Development of a highly fecund inbred strain of mice

Marte Holt et al. Mamm Genome. 2004 Dec.

Abstract

A highly fecund inbred mouse line has been established from the Quackenbush Swiss (QS) outbred strain by full-sib inbreeding combined with selection for high number of pups born alive (NBA) and low interlitter interval (ILI). After more than 50 generations of inbreeding and selection, this line, named QSi5, has an NBA of 13.4 and an ILI of 29 days, averaged over the first four parities, and a total productivity of 50.7 NBA. With its exceptional reproductive performance, this line will be very useful in the creation of resources (including advanced intercross lines) for analysis of quantitative trait loci for a wide range of traits, and for the cost-effective creation of congenic lines.

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