Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Dec;15(12):951-9.
doi: 10.1007/s00335-004-3030-8.

Development of a highly fecund inbred strain of mice

Marte Holt  1 , Frank W Nicholas, John W James, Chris Moran, Ian C A Martin
Affiliations

Development of a highly fecund inbred strain of mice

Marte Holt et al. Mamm Genome. 2004 Dec.

Abstract

A highly fecund inbred mouse line has been established from the Quackenbush Swiss (QS) outbred strain by full-sib inbreeding combined with selection for high number of pups born alive (NBA) and low interlitter interval (ILI). After more than 50 generations of inbreeding and selection, this line, named QSi5, has an NBA of 13.4 and an ILI of 29 days, averaged over the first four parities, and a total productivity of 50.7 NBA. With its exceptional reproductive performance, this line will be very useful in the creation of resources (including advanced intercross lines) for analysis of quantitative trait loci for a wide range of traits, and for the cost-effective creation of congenic lines.

PubMed Disclaimer

References

    1. Genet Res. 1967 Aug;10(1):73-80 - PubMed
    1. Nat Rev Genet. 2001 Jun;2(6):437-45 - PubMed
    1. Lab Anim Care. 1969 Apr;19(2):214-20 - PubMed
    1. Mamm Genome. 1999 Jun;10(6):645-8 - PubMed
    1. Genetics. 1994 Mar;136(3):937-51 - PubMed

LinkOut - more resources