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Review
. 2004 Aug;5(8):827-37.

Development of antibiotics and the future of marine microorganisms to stem the tide of antibiotic resistance

Noer Kasanah  1 , Mark T Hamann
Affiliations
Review

Development of antibiotics and the future of marine microorganisms to stem the tide of antibiotic resistance

Noer Kasanah et al. Curr Opin Investig Drugs. 2004 Aug.

Abstract

Antibiotics remain essential tools in the control of infectious diseases. With the emergence of new diseases, resistant forms of diseases such as tuberculosis and malaria, as well as the emergence of multidrug-resistant bacteria, it has become essential to develop novel antibiotics. Development of the existing antibiotics involved three strategies, including discovery of new target sites, modification of existing antibiotic structures, and the identification of new resources for novel antibiotics. Marine microorganisms have clearly become an essential new resource in the discovery of new antibiotic leads.

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Figures

Figure 1
Figure 1
The structures of massetolide A and haliangicin.
Figure 2
Figure 2
The structures of macrolactins.
Figure 3
Figure 3
The structure of antibiotics isolated from Bacillus laterosporus.
Figure 4
Figure 4
The structures of arisostatins.
Figure 5
Figure 5
The structures of lomaiviticins.
Figure 6
Figure 6
The structure of pelagiomicin A.
Figure 7
Figure 7
The structure of thiocoraline.
Figure 8
Figure 8
The structure of parimycin.
Figure 9
Figure 9
The structure of IB-00208.
Figure 10
Figure 10
The structures of YM-266183 and YM-266184.
Figure 11
Figure 11
The structures of chalcomycins.
Figure 12
Figure 12
The structures of zopfiellamides.
Figure 13
Figure 13
The structure of pestalone.
Figure 14
Figure 14
The structure of halorosellinic acid.
Figure 15
Figure 15
The structures of trichodermamides.
Figure 16
Figure 16
The structure of varixanthone.
Figure 17
Figure 17
The structure of YM-202204.
See this image and copyright information in PMC

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