Developmental waves in myxobacteria: A distinctive pattern formation mechanism

Abstract

In early stages of their development, starving myxobacteria organize their motion to produce a periodic pattern of traveling cell density waves. These waves arise from coordination of individual cell reversals by contact signaling when they collide. Unlike waves generated by reaction-diffusion instabilities, which annihilate on collision, myxobacteria waves appear to pass through one another unaffected. Here we analyze a mathematical model of these waves developed earlier [Proc. Natl. Acad. Sci. USA 98, 14 913 (2001)]]. The mechanisms which generate and maintain the density waves are clearly revealed by tracing the reversal loci of individual cells. An evolution equation of reversal point density is derived in the weak-signaling limit. Linear stability analysis determines parameters favorable for the development of the waves. Numerical solutions demonstrate the stability of the fully developed nonlinear waves.