Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Oct-Dec;8(4):509-18.
doi: 10.1111/j.1582-4934.2004.tb00475.x.

Endothelial progenitor cells: a source for therapeutic vasculogenesis?

Holger Rumpold  1 , Dominik Wolf, Ruth Koeck, Eberhard Gunsilius
Affiliations
Review

Endothelial progenitor cells: a source for therapeutic vasculogenesis?

Holger Rumpold et al. J Cell Mol Med. 2004 Oct-Dec.

Abstract

Angiogenesis has been defined as sprouting of blood vessels from pre-existing vascular structures. Risau and co-workers defined the term vasculogenesis while studying the formation of new blood vessels in embryoid bodies. This process is characterized by the recruitment of endothelial progenitor cells (EPC) to sites of new vessel formation with subsequent differentiation of EPC into mature endothelial cells, extensively proliferating in situ. Data from recent years provided evidence that EPC also exist in the adult and contribute to new vessel formation, a process called post-natal vasculogenesis. The existence of EPC has been convincingly shown in both, animals and humans. They represent a perfect cellular progenitor cell population for the ex vivo generation of EC, which in turn serve as cellular source for therapeutic vasculogenesis or tumor targeting. This review provides an overview on this hot topic of cellular-based therapeutic concepts and the therapeutic potential of ex vivo generated EPC.

PubMed Disclaimer

References

    1. His W., Lecithoblast und Angioblast der Wirbelthiere. Abhandl KS Ges Wiss Math Phys 22: 171, 1901.
    1. Sabin F.R., Preliminary note on the differentiation of angioblasts and the method by which they produce bloodvessels, blood‐plasma and red blood cells as seen in the living chick. Anatomical Record 13: 199–204, 1917. - PubMed
    1. Shalaby F., Rossant J., Yamaguchi T.P., Gertsenstein M., Wu X.F., Breitman M.L., Schuh A.C., Failure of blood‐island formation and vasculogenesis in Flk‐1‐deficient mice, Nature, 376: 62–66, 1995. - PubMed
    1. Ferrara N., Carver‐Moore K., Chen H., Dowd M., Lu L., O'Shea K.S., Powell‐Braxton L., Hillan K.J., Moore M.W., Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene, Nature, 380: 439–442, 1996. - PubMed
    1. Eichmann A., Corbel C., Nataf V., Vaigot P., Breant C., Le Douarin N.M., Ligand‐dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2, Proc Natl Acad Sci USA, 94: 5141–5146, 1997. - PMC - PubMed

MeSH terms

Substances