doi: 10.1016/j.bmcl.2004.11.001.
Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist
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- PMID: 15603933
- DOI: 10.1016/j.bmcl.2004.11.001
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Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist
Bioorg Med Chem Lett.
.
Abstract
The discovery of a novel, potent and selective beta(3)-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good beta(3)-AR activity and selectivity, was identified and pharmacokinetics were investigated.
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