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Review
. 2004 Dec 18;329(7480):1464-7.
doi: 10.1136/bmj.329.7480.1464.

Polymyositis, invasion of non-necrotic muscle fibres, and the art of repetition

Gerald J D Hengstman  1 , Baziel G M van Engelen
Affiliations
Review

Polymyositis, invasion of non-necrotic muscle fibres, and the art of repetition

Gerald J D Hengstman et al. BMJ. .

Abstract

The presence of cellular inflammatory infiltrates with invasion of non-necrotic muscle fibres has become a prerequisite for the diagnosis of polymyositis, but a structured literature search shows that the research evidence is insufficiently strong for this histological feature to be used as a diagnostic criterion

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Figures

Figure 1
Figure 1
Polymyositis is histopathologically characterised by cellular inflammatory infiltrates with invasion of non-necrotic muscle fibres
Figure 2
Figure 2
Results of reference search to find original data to support the statement “in polymyositis, multifocal lymphocytic infiltrates surround and invade healthy muscle fibres” made by Dalakas et al (numbers refer to references)
See this image and copyright information in PMC

References

    1. Dalakas MC, Hohlfeld R. Polymyositis and dermatomyositis. Lancet 2003;362: 971-82. - PubMed
    1. Barohn RJ, Amato AA, Sahenk Z, Kissel JT, Mendell JR. Inclusion body myositis: explanation for poor response to immunosuppressive therapy. Neurology 1995;45: 1302-4. - PubMed
    1. Amato AA, Gronseth GS, Jackson CE, Wolfe GI, Katz JS, Bryan WW, et al. Inclusion body myositis: clinical and pathological boundaries. Ann Neurol 1996;40: 581-6. - PubMed
    1. Miller FW, Rider LG, Plotz PH, Isenberg DA, Oddis CV. Diagnostic criteria for polymyositis and dermatomyositis. Lancet 2003;362: 1762-3. - PubMed
    1. Van der Meulen MFG, Bronner IM, Hoogendijk JE, Burger H, Van Venrooij WJ, Voskuyl AE, et al. Polymyositis: an overdiagnosed entity. Neurology 2003;61: 316-21. - PubMed