Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Dec 17;306(5704):2111-5.
doi: 10.1126/science.1103709.

bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS

Heather A Arnett  1 , Stephen P J Fancy, John A Alberta, Chao Zhao, Sheila R Plant, Sovann Kaing, Cedric S Raine, David H Rowitch, Robin J M Franklin, Charles D Stiles
Affiliations
Free article

bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS

Heather A Arnett et al. Science. .
Free article

Abstract

Olig1 and Olig2 are closely related basic helix-loop-helix (bHLH) transcription factors that are expressed in myelinating oligodendrocytes and their progenitor cells in the developing central nervous system (CNS). Olig2 is necessary for the specification of oligodendrocytes, but the biological functions of Olig1 during oligodendrocyte lineage development are poorly understood. We show here that Olig1 function in mice is required not to develop the brain but to repair it. Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms