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Review
. 2004 Oct;40(10):853-63.
doi: 10.1358/dot.2004.40.10.863745.

Aprepitant: an oral NK1 antagonist for the prevention of nausea and vomiting induced by highly emetogenic chemotherapy

Kelly Pendergrass  1 , Richard Hargreaves, Kevin J Petty, Alexandra D Carides, Judith K Evans, Kevin J Horgan
Affiliations
Review

Aprepitant: an oral NK1 antagonist for the prevention of nausea and vomiting induced by highly emetogenic chemotherapy

Kelly Pendergrass et al. Drugs Today (Barc). 2004 Oct.

Abstract

This paper reviews the clinical profile of aprepitant, the first neurokinin-1 (NK(1)) receptor antagonist to be approved for use in the prevention of chemotherapy-induced nausea and vomiting. When given to patients receiving highly emetogenic chemotherapy, aprepitant in combination with a 5-hydroxytryptamine type-3 (5HT(3)) receptor antagonist and a corticosteroid provides significantly improved protection from chemotherapy-induced nausea and vomiting over that which has been previously achievable with current antiemetics.

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