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Meta-Analysis
. 2004 Dec;17(12 Pt 1):1100-6.
doi: 10.1016/j.amjhyper.2004.07.014.

Genome scan meta-analysis for hypertension

Wenlei Liu  1 , Wei Zhao, Gary A Chase
Affiliations
Meta-Analysis

Genome scan meta-analysis for hypertension

Wenlei Liu et al. Am J Hypertens. 2004 Dec.

Abstract

Background: Genome scans for hypertension have yielded inconsistent results. The non-replication of significant or suggestive linkage might be due to lack of power of individual studies. Here, we conducted a genome scan meta-analysis for hypertension in an attempt to increase statistical power and to enhance evidence of linkage.

Methods: A newly developed Genome Search Meta-analysis (GSMA) method was applied to pool the results obtained from six scans reported in five papers.

Results: Our analysis did not find any regions with genome-wide significant linkage to hypertension. We did identify several regions with suggestive linkage, including 2p, 5q, 6q, 8p, 9p, 9q, and 11q.

Conclusions: It seems that no region has a uniformly large impact on hypertension and that susceptibility genes for hypertension may be very difficult to detect.

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