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Review
. 2005 Feb;42(4):557-60.
doi: 10.1016/j.molimm.2004.07.041.

Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses

Silvana Gaudieri  1 , David Nolan, Elizabeth McKinnon, Campbell S Witt, Simon Mallal, Frank T Christiansen
Affiliations
Review

Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses

Silvana Gaudieri et al. Mol Immunol. 2005 Feb.

Abstract

The Killer Ig-like receptors (KIRs) on NK cells regulate NK activity via the recognition of specific HLA class I products on the surface of target cells. To investigate the level at which these genetically polymorphic receptors and ligands influence HIV-1 disease progression, we examined the effect of KIR and HLA genotype on HIV outcome. We observed a significant association between particular combinations of KIR epitopes expressed by HLA-B/-C haplotypes and propose that the repertoire of KIR epitopes expressed by HLA-B and HLA-C alleles within the context of particular haplotypes may be an important component of the NK mediated immune response to HIV and/or other infectious pathogens.

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