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Review
. 2004 Dec;6(6):539-45.
doi: 10.1016/j.ccr.2004.12.001.

Crosslinks and crosstalk: human cancer syndromes and DNA repair defects

Mary A Risinger  1 , Joanna Groden
Affiliations
Free article
Review

Crosslinks and crosstalk: human cancer syndromes and DNA repair defects

Mary A Risinger et al. Cancer Cell. 2004 Dec.
Free article

Abstract

A subset of human cancer syndromes result from inherited defects in genes responsible for DNA repair. During the past few years, discoveries concerning the intersection of certain DNA repair processes have increased our understanding of how the disruption of specific DNA repair mechanisms leads to genomic instability and tumorigenesis. This review focuses on the human genes MUTYH, BRCA2/FANCD1, and BLM.

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