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Comment
. 2004 Dec 17;119(6):733-5.
doi: 10.1016/j.cell.2004.12.005.

Around the world of DNA damage INO80 days

Bradley R Cairns  1
Affiliations
Comment

Around the world of DNA damage INO80 days

Bradley R Cairns. Cell. .

Abstract

DNA damage is detected and repaired in the context of chromatin. In this issue of Cell, van Attikum et al. (2004) and Morrison et al. (2004) demonstrate that double-stranded break repair involves the recruitment of a specialized chromatin remodeling complex, INO80, through an interaction with phosphorylated histone H2A.

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Figures

Figure 1
Figure 1. Chromatin in DSB Repair in S. cerevisiae
Following break initiation, DNA ends are bound by yKu and MRX complex (data not shown). The checkpoint kinases Mec1 and Tel1 are recruited to the break and phosphorylate H2A Ser129. This is followed by NuA4 recruitment (a histone acetyltransferase) and acetylation of the region. INO80 and SWR1 are then recruited. The chromatin remodeling activity of INO80 is required for the appearance of the processed 3′ ssDNA overhang, which may be facilitated by the removal of nucleosomes from the region. The presence of SWR1 may cause histone H2A replacement for the histone H2A variant Htz1at the DSB but has not been tested. INO80 and SWR1 may have chromatin remodeling roles during repair by HR (see text; data not shown due to space limitations).
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References

    1. Downs JA, Allard S, Jobin-Robitaille O, Javaheri A, Auger A, Bouchard N, Kron SJ, Jackson SP, Côté J. Mol. Cell. 2004;16 in press. Published online December 16, 2004. 10.1016/S1097276504007580. - PubMed
    1. Fritsch O, Benvenuto G, Bowler C, Molinier J, Hohn B. Mol. Cell. 2004;16:479–485. - PubMed
    1. Jonsson ZO, Jha S, Wohlschlegel JA, Dutta A. Mol. Cell. 2004;16:465–477. - PubMed
    1. Kusch T, Florens L, Macdonald WH, Swanson SK, Glaser RL, Yates Iii JR, Abmayr SM, Washburn MP, Workman JL. Science. 2004 in press. Published online November 4, 2004. 0: 11034551. - PubMed
    1. Mizuguchi G, Shen X, Landry J, Wu WH, Sen S, Wu C. Science. 2004;303:343–348. - PubMed

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