The ways of PARP
- PMID: 15607968
- DOI: 10.1016/j.cell.2004.12.002
The ways of PARP
Abstract
Two papers in this issue of Cell describe two roles of poly(ADP-ribose) polymerase (PARP) in modulating chromatin structure: as a structural component replacing linker histone (Kim et al., 2004) and as a constituent of a corepressor complex poised to dismiss repression upon receipt of an activating signal (Ju et al., 2004).
Comment on
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NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1.Cell. 2004 Dec 17;119(6):803-14. doi: 10.1016/j.cell.2004.11.002. Cell. 2004. PMID: 15607977
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Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway.Cell. 2004 Dec 17;119(6):815-29. doi: 10.1016/j.cell.2004.11.017. Cell. 2004. PMID: 15607978
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