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. 2005 Jan;76(1):118-20.
doi: 10.1136/jnnp.2004.040220.

Dopamine transporter SPECT in patients with mitochondrial disorders

M Minnerop  1 , C Kornblum, A Y Joe, K Tatsch, W S Kunz, T Klockgether, U Wüllner, M J Reinhardt
Affiliations

Dopamine transporter SPECT in patients with mitochondrial disorders

M Minnerop et al. J Neurol Neurosurg Psychiatry. 2005 Jan.

Abstract

Background: Mitochondrial disorders may affect basal ganglia function. In addition, decreased activity of complex I of the mitochondrial electron transport chain has been linked to the pathogenesis of dopaminergic cell loss in Parkinson's disease. Objective : To investigate the dopaminergic system in patients with known mitochondrial disorders and complex I deficiency.

Methods: Dopamine transporter density was studied in 10 female patients with mitochondrial complex I deficiency by (123)I-FP-CIT (N-beta-fluoropropyl-2beta-carbomethyl-3beta-(4-iodophenyl)-nortropane) SPECT.

Results: No differences in (123)I-FP-CIT striatal binding ratios were observed and no correlation of the degree of complex I deficiency and striatal binding ratios could be detected.

Conclusions: These data argue against the possibility that mitochondrial complex I deficiency by itself is sufficient to elicit dopaminergic cell loss.

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