VFDB: a reference database for bacterial virulence factors

Abstract

Bacterial pathogens continue to impose a major threat to public health worldwide in the 21st century. Intensified studies on bacterial pathogenesis have greatly expanded our knowledge about the mechanisms of the disease processes at the molecular level over the last decades. To facilitate future research, it becomes necessary to form a database collectively presenting the virulence factors (VFs) of various medical significant bacterial pathogens. The aim of virulence factor database (VFDB) (http://www.mgc.ac.cn/VFs/) is to provide such a source for scientists to rapidly access to current knowledge about VFs from various bacterial pathogens. VFDB is comprehensive and user-friendly. One can search VFDB by browsing each genus or by typing keywords. Furthermore, a BLAST search tool against all known VF-related genes is also available. VFDB provides a unified gateway to store, search, retrieve and update information about VFs from various bacterial pathogens.

Figure 1

The main page contents of (A) the genus Listeria, (B) the Listeria hexose phosphate transporter, (C) the Listeria monocytogenes LIPI-1 pathogenicity island EGD-e and (D) the Listeria hpt gene page. The text in the box in the bottom of (A) explains the ‘zipper mechanism’ used by the organism during invasion.