CYGD: the Comprehensive Yeast Genome Database
- PMID: 15608217
- PMCID: PMC540007
- DOI: 10.1093/nar/gki053
CYGD: the Comprehensive Yeast Genome Database
Abstract
The Comprehensive Yeast Genome Database (CYGD) compiles a comprehensive data resource for information on the cellular functions of the yeast Saccharomyces cerevisiae and related species, chosen as the best understood model organism for eukaryotes. The database serves as a common resource generated by a European consortium, going beyond the provision of sequence information and functional annotations on individual genes and proteins. In addition, it provides information on the physical and functional interactions among proteins as well as other genetic elements. These cellular networks include metabolic and regulatory pathways, signal transduction and transport processes as well as co-regulated gene clusters. As more yeast genomes are published, their annotation becomes greatly facilitated using S.cerevisiae as a reference. CYGD provides a way of exploring related genomes with the aid of the S.cerevisiae genome as a backbone and SIMAP, the Similarity Matrix of Proteins. The comprehensive resource is available under http://mips.gsf.de/genre/proj/yeast/.
Similar articles
-
MIPS: analysis and annotation of genome information in 2007.Nucleic Acids Res. 2008 Jan;36(Database issue):D196-201. doi: 10.1093/nar/gkm980. Epub 2007 Dec 23. Nucleic Acids Res. 2008. PMID: 18158298 Free PMC article.
-
Fungal BLAST and Model Organism BLASTP Best Hits: new comparison resources at the Saccharomyces Genome Database (SGD).Nucleic Acids Res. 2005 Jan 1;33(Database issue):D374-7. doi: 10.1093/nar/gki023. Nucleic Acids Res. 2005. PMID: 15608219 Free PMC article.
-
FGDB: a comprehensive fungal genome resource on the plant pathogen Fusarium graminearum.Nucleic Acids Res. 2006 Jan 1;34(Database issue):D456-8. doi: 10.1093/nar/gkj026. Nucleic Acids Res. 2006. PMID: 16381910 Free PMC article.
-
Transcriptional networks: reverse-engineering gene regulation on a global scale.Curr Opin Microbiol. 2004 Dec;7(6):638-46. doi: 10.1016/j.mib.2004.10.009. Curr Opin Microbiol. 2004. PMID: 15556037 Review.
-
[Decade of genomics--methods for genome investigation in yeast Saccharomyces cerevisiae].Postepy Biochem. 2006;52(4):435-47. Postepy Biochem. 2006. PMID: 17536513 Review. Polish.
Cited by
-
Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA.EMBO J. 2006 May 17;25(10):2142-54. doi: 10.1038/sj.emboj.7601105. Epub 2006 Apr 27. EMBO J. 2006. PMID: 16642040 Free PMC article.
-
MIPS: analysis and annotation of genome information in 2007.Nucleic Acids Res. 2008 Jan;36(Database issue):D196-201. doi: 10.1093/nar/gkm980. Epub 2007 Dec 23. Nucleic Acids Res. 2008. PMID: 18158298 Free PMC article.
-
Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae.RNA. 2011 Jun;17(6):1111-9. doi: 10.1261/rna.2653411. Epub 2011 Apr 25. RNA. 2011. PMID: 21518805 Free PMC article.
-
Microarray data mining: a novel optimization-based approach to uncover biologically coherent structures.BMC Bioinformatics. 2008 Jun 6;9:268. doi: 10.1186/1471-2105-9-268. BMC Bioinformatics. 2008. PMID: 18538024 Free PMC article.
-
The roles of whole-genome and small-scale duplications in the functional specialization of Saccharomyces cerevisiae genes.PLoS Genet. 2013;9(1):e1003176. doi: 10.1371/journal.pgen.1003176. Epub 2013 Jan 3. PLoS Genet. 2013. PMID: 23300483 Free PMC article.
References
-
- Mewes H.W., Albermann,K., Bahr,M., Frishman,D., Gleissner,A., Hani,J., Heumann,K., Kleine,K., Maierl,A., Oliver,S.G. et al. (1997) Overview of the yeast genome. Nature, 387, 7–8. - PubMed
-
- Dujon B. (1998) European Functional Analysis Network (EUROFAN) and the functional analysis of the Saccharomyces cerevisiae genome. Electrophoresis, 19, 617–624. - PubMed
-
- Souciet J.L., Aigle,M., Artiguenave,F., Blandin,G., Bolotin-Fukuhara,M., Bon,E., Brottier,P., Casaregola,S., de Montigny,J., Dujon,B. et al. (2000) Genomic exploration of the Hemiascomycetous yeasts: 1. A set of yeast species for molecular evolution studies. FEBS Lett., 487, 3–12. - PubMed
-
- Kellis M., Patterson,N., Endrizzi,M., Birren,B. and Lander,E.S. (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature, 423, 241–254. - PubMed
-
- Cliften P., Sudarsanam,P., Desikan,A., Fulton,L., Fulton,B., Majors,J., Waterston,R., Cohen,B.A. and Johnston,M. (2003) Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science, 301, 71–76. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials