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. 2005 Jan 1;33(Database issue):D471-5.
doi: 10.1093/nar/gki113.

The Mouse Genome Database (MGD): from genes to mice--a community resource for mouse biology

Janan T Eppig  1 , Carol J Bult, James A Kadin, Joel E Richardson, Judith A Blake, A Anagnostopoulos, R M Baldarelli, M Baya, J S Beal, S M Bello, W J Boddy, D W Bradt, D L Burkart, N E Butler, J Campbell, M A Cassell, L E Corbani, S L Cousins, D J Dahmen, H Dene, A D Diehl, H J Drabkin, K S Frazer, P Frost, L H Glass, C W Goldsmith, P L Grant, M Lennon-Pierce, J Lewis, I Lu, L J Maltais, M McAndrews-Hill, L McClellan, D B Miers, L A Miller, L Ni, J E Ormsby, D Qi, T B K Reddy, D J Reed, B Richards-Smith, D R Shaw, R Sinclair, C L Smith, P Szauter, M B Walker, D O Walton, L L Washburn, I T Witham, Y Zhu; Mouse Genome Database Group
Affiliations

The Mouse Genome Database (MGD): from genes to mice--a community resource for mouse biology

Janan T Eppig et al. Nucleic Acids Res. .

Abstract

The Mouse Genome Database (MGD) forms the core of the Mouse Genome Informatics (MGI) system (http://www.informatics.jax.org), a model organism database resource for the laboratory mouse. MGD provides essential integration of experimental knowledge for the mouse system with information annotated from both literature and online sources. MGD curates and presents consensus and experimental data representations of genotype (sequence) through phenotype information, including highly detailed reports about genes and gene products. Primary foci of integration are through representations of relationships among genes, sequences and phenotypes. MGD collaborates with other bioinformatics groups to curate a definitive set of information about the laboratory mouse and to build and implement the data and semantic standards that are essential for comparative genome analysis. Recent improvements in MGD discussed here include the enhancement of phenotype resources, the re-development of the International Mouse Strain Resource, IMSR, the update of mammalian orthology datasets and the electronic publication of classic books in mouse genetics.

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Figures

Figure 1
Figure 1
The new IMSR is a searchable online database of mouse strains and stocks available worldwide, including inbred, mutant and genetically engineered mice. The goal of the IMSR is to assist the international scientific community in locating and obtaining mouse resources for research. The data content found in the IMSR is as it was supplied by data provider sites.
Figure 2
Figure 2
Mammalian Orthology Detail Page. The Mammalian Orthology Query Results page presents a table of results from MGI orthology curation. The table includes species, symbol, chromosome, external and internal accession IDs and criteria for the assertions. The criteria include both a statement of evidence and a citation. Hypertext links are incorporated as appropriate. Comparative chromosome map visualizations between any two of the species can be accessed from this page. These data are updated nightly.
Figure 3
Figure 3
Electronic publication of classic books in mouse genetics. MGI offers electronic versions of key out-of-print books in mouse genetics, Mouse Genetics by Lee M. Silver (http://www.informatics.jax.org/silver/) and The Coat Colors of Mice by Willys K. Silvers (http://www.informatics.jax.org/wksilvers/). Gene symbols in both books link to MGI gene detail pages where readers can access all the information MGI has assembled for that gene, including phenotypic alleles, nucleotide and protein sequence, mapping and expression data and GO annotations. References cited in the books are linked to PubMed or MGI reference detail pages, which, in turn are linked to additional curated information in MGI.
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References

    1. Bult C.J., Blake,J.A., Richardson,J.E., Kadin,J.A., Eppig,J.T. and the Mouse Genome Database Group (2004) The Mouse Genome Database (MGD): integrating biology with the genome. Nucleic Acids Res., 32, D476–D481. - PMC - PubMed
    1. Blake J.A., Richardson.J.E., Bult,C.J., Kadin,J.A., Eppig,J.T. and the Mouse Genome Database Group (2003) MGD: the Mouse Genome Database. Nucleic Acids Res., 31, 193–195. - PMC - PubMed
    1. Hill D.P., Begley,D.A., Finger,J.H., Hayamizu,T.F., McCright,I.J., Smith,C.M., Beal,J.S., Corbani,L.E., Blake,J.A., Eppig,J.T., Kadin,J.A., Richardson,J.E. and Ringwald,M. (2004) The Mouse Gene Expression Database (GXD): updates and enhancements. Nucleic Acids Res., 32, D568–D571. - PMC - PubMed
    1. Näf D., Krupke,D.M., Sundberg,J.P., Eppig,J.T. and Bult,C.J. (2002) The mouse tumor biology database: a public resource for cancer genetics and pathology of the mouse. Cancer Res., 62, 1235–1240. - PubMed
    1. The Gene Ontology Consortium (2004) The Gene Ontology (GO) Database and Informatics Resource. Nucleic Acids Res., 32, D258–D261. - PMC - PubMed

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