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Review
. 2004;3(5):20.
doi: 10.1186/jbiol19. Epub 2004 Dec 17.

All systems GO for understanding mouse gene function

Chris Holmes  1 , Steve D M Brown
Affiliations
Review

All systems GO for understanding mouse gene function

Chris Holmes et al. J Biol. 2004.

Abstract

It is widely supposed that the tissue specificity of gene expression indicates gene function. Now, an extensive analysis of gene expression in the mouse reveals that quantitative measurement of expression levels in different tissues can contribute powerfully to the prediction of gene function.

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Figures

Figure 1
Figure 1
Examples of the results in Zhang et al. [6] (reproduced with permission). Each row of the image represents a gene and each column a tissue (labeled at the bottom), with the color indicating the ratio of expression levels. Clusters of genes coordinately regulated in certain tissues correlate with the biological functions indicated on the right. See the complete article [6] for a full version of this figure.
See this image and copyright information in PMC

Comment on

  • The functional landscape of mouse gene expression.
    Zhang W, Morris QD, Chang R, Shai O, Bakowski MA, Mitsakakis N, Mohammad N, Robinson MD, Zirngibl R, Somogyi E, Laurin N, Eftekharpour E, Sat E, Grigull J, Pan Q, Peng WT, Krogan N, Greenblatt J, Fehlings M, van der Kooy D, Aubin J, Bruneau BG, Rossant J, Blencowe BJ, Frey BJ, Hughes TR. Zhang W, et al. J Biol. 2004;3(5):21. doi: 10.1186/jbiol16. Epub 2004 Dec 6. J Biol. 2004. PMID: 15588312 Free PMC article.

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