Review
doi: 10.1016/j.chembiol.2004.11.011.
The structure of mammalian fatty acid synthase turned back to front
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- PMID: 15610841
- DOI: 10.1016/j.chembiol.2004.11.011
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Review
The structure of mammalian fatty acid synthase turned back to front
Chem Biol.
2004 Dec.
Abstract
On page 1667 of this issue, Stuart Smith and colleagues [1] demonstrate that the animal fatty acid synthase is a head-to-head dimer rather than the head-to-tail dimer depicted in textbooks. This has important ramifications for the mechanisms of other multifunctional enzymes such as polyketide synthases [2].
Comment on
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Head-to-head coiled arrangement of the subunits of the animal fatty acid synthase.Chem Biol. 2004 Dec;11(12):1667-76. doi: 10.1016/j.chembiol.2004.09.016. Chem Biol. 2004. PMID: 15610851
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