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. 2004 Dec;2(12):2152-5.
doi: 10.1111/j.1538-7836.2004.01050.x.

High risk of recurrent venous thromboembolism in men

T Baglin  1 , R Luddington, K Brown, C Baglin
Affiliations
Free article

High risk of recurrent venous thromboembolism in men

T Baglin et al. J Thromb Haemost. 2004 Dec.
Free article

Abstract

Background: We have analyzed the influence of gender on risk of recurrence after a first episode of venous thromboembolism (VTE).

Methods: The Cambridge Venous Thromboembolism Study (CVTE) is a single-center study of a cohort of unselected patients with a first episode of objectively proven VTE.

Results: Recurrence rates were significantly higher in men compared with women [log rank chi2=11.82; hazard ratio (HR) 2.66; 95% confidence interval (CI) 1.49, 4,77; P=0.0006]. The cumulative recurrence rate at 2 years was 19.2% in men and 7.7% in women. There was no evidence of a difference in recurrence between men with or without thrombophilia (log rank chi2=0.03; HR 1.08; 95% CI 0.49, 2.37; P=0.855). The high recurrence rate in men compared with women was still observed when only patients with idiopathic VTE were analyzed (log rank chi2=4.38; HR 2.31; 95% CI 1.027, 5.20; P=0.0363). The recurrence risk was highest in men with a first idiopathic event at 25.7% compared with 11.7% for women in the same category.

Conclusion: The risk of recurrent VTE is higher in men than in women.

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