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. 2004 Sep;35(7):659-65.
doi: 10.1007/s10735-004-2660-1.

Development and validation of computational models of cellular interaction

R H Smallwood  1 , W M L Holcombe, D C Walker
Affiliations
Free article

Development and validation of computational models of cellular interaction

R H Smallwood et al. J Mol Histol. 2004 Sep.
Free article

Abstract

In this paper we take the view that computational models of biological systems should satisfy two conditions - they should be able to predict function at a systems biology level, and robust techniques of validation against biological models must be available. A modelling paradigm for developing a predictive computational model of cellular interaction is described, and methods of providing robust validation against biological models are explored, followed by a consideration of software issues.

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