An expedient synthesis of the repeating unit of the acidic polysaccharide of the bacteriolytic complex of lysoamidase

Abstract

The first synthesis of the trisaccharide repeating unit of the acidic polysaccharide of the bacteriolytic complex of lysoamidase is presented. The construction is based on a linear glycosylation strategy that starts from the reducing end and employs thio- and selenoglycosides in a highly stereoselective manner by a single set of activation conditions. The thus-formed trisaccharide is selectively deprotected and oxidised, after which a final deprotection step furnishes the desired repeating unit.