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. 2005 Jan;49(1):418-20.
doi: 10.1128/AAC.49.1.418-420.2005.

Streptococcus pyogenes pharyngeal isolates with reduced susceptibility to ciprofloxacin in Spain: mechanisms of resistance and clonal diversity

Sebastián Albertí  1 , Guadalupe Cortés, Cesar García-Rey, Carmen Rubio, Fernando Baquero, José Angel García-Rodríguez, Emilio Bouza, Lorenzo Aguilar
Affiliations

Streptococcus pyogenes pharyngeal isolates with reduced susceptibility to ciprofloxacin in Spain: mechanisms of resistance and clonal diversity

Sebastián Albertí et al. Antimicrob Agents Chemother. 2005 Jan.

Abstract

A survey of emm gene sequences and an analysis of the pulsed-field electrophoretic profiles of 30 Streptococcus pyogenes isolates with reduced susceptibilities to ciprofloxacin detected the prevalence of isolates with emm type 6 and considerable genetic diversity among isolates. The mechanism of ciprofloxacin resistance in these isolates was based on point mutations in topoisomerase IV subunit C encoded by parC, mainly replacement of serine-79 by alanine.

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Figures

FIG. 1.
FIG. 1.
Representative PFGE types of ciprofloxacin-resistant S. pyogenes isolated between 1998 and 1999 in Spain. S. pyogenes genomic DNA was isolated, restricted with SfiI, and analyzed by PFGE. Letters above the lanes refer to PFGE types, and the numbers below the lanes refer to the number of isolates of each type. Molecular size markers (in kilobases) are indicated on the left.
See this image and copyright information in PMC

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