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. 2005 Jan;49(1):461-3.
doi: 10.1128/AAC.49.1.461-463.2005.

Pharmacodynamic evaluation of extending the administration time of meropenem using a Monte Carlo simulation

Ben M Lomaestro  1 , G L Drusano
Affiliations

Pharmacodynamic evaluation of extending the administration time of meropenem using a Monte Carlo simulation

Ben M Lomaestro et al. Antimicrob Agents Chemother. 2005 Jan.

Abstract

A Monte Carlo simulation demonstrated that 1 g of meropenem (MEM) every 8 h (q8h) (3-h infusion) has a higher target attainment rate against Pseudomonas aeruginosa than either 500 mg of MEM q8h (3-h infusion) or 0.5 g of imipenem-cilastatin (I-C) q6h (1-h infusion). For other pathogens, 500 mg of MEM q8h was equivalent or superior to I-C.

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