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Review
. 2005 Jan;39(1):52-62.
doi: 10.1136/bjsm.2003.011247.

Complex systems model of fatigue: integrative homoeostatic control of peripheral physiological systems during exercise in humans

E V Lambert  1 , A St Clair Gibson, T D Noakes
Affiliations
Review

Complex systems model of fatigue: integrative homoeostatic control of peripheral physiological systems during exercise in humans

E V Lambert et al. Br J Sports Med. 2005 Jan.

Abstract

Fatigue is hypothesised as being the result of the complex interaction of multiple peripheral physiological systems and the brain. In this new model, all changes in peripheral physiological systems such as substrate depletion or metabolite accumulation act as afferent signallers which modulate control processes in the brain in a dynamic, non-linear, integrative manner.

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