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. 2004 Dec;68(12):2643-5.
doi: 10.1271/bbb.68.2643.

The 9cis,11trans,13cis isomer of conjugated linolenic acid reduces apolipoprotein B100 secretion and triacylglycerol synthesis in HepG2 cells

Keisuke Arao  1 , Hiroaki Yotsumoto, Seo-Young Han, Koji Nagao, Teruyoshi Yanagita
Affiliations
Free article

The 9cis,11trans,13cis isomer of conjugated linolenic acid reduces apolipoprotein B100 secretion and triacylglycerol synthesis in HepG2 cells

Keisuke Arao et al. Biosci Biotechnol Biochem. 2004 Dec.
Free article

Abstract

The physiological effects of 9cis,11trans,13cis-conjugated linolenic acid (9c,11t,13c-CLNA), one of the CLNA isomers, were studied in human hepatoma HepG2 cells. 9c,11t,13c-CLNA significantly decreased apolipoprotein B100 secretion compared with alpha-linolenic acid (alpha-LNA). The uptake of (14)C-oleate into newly synthesized cellular triacylglycerol was also decreased by 9c,11t,13c-CLNA more than by alpha-LNA treatment. This is the first study to show the hypolipidemic effect of 9c,11t,13c-CLNA.

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