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Case Reports
. 2005 Jan;58(1):104-6.
doi: 10.1136/jcp.2003.015537.

Langerhans cell histiocytosis in sequential discordant lymphoma

K Adu-Poku  1 , D W Thomas, M K Khan, C S Holgate, M E F Smith
Affiliations
Case Reports

Langerhans cell histiocytosis in sequential discordant lymphoma

K Adu-Poku et al. J Clin Pathol. 2005 Jan.

Abstract

B cell non-Hodgkin lymphoma of the follicular subtype (grade 3/3) affecting the nasopharynx and breast, and containing foci of Langerhans cell histiocytosis, was diagnosed in a 56 year old white woman who was a longstanding heavy smoker. Four years before this she had developed stage 1a mixed cellularity Hodgkin lymphoma affecting the right inguinal region, which was treated by irradiation and chemotherapy without recurrence. Review of the original Hodgkin lymphoma histology demonstrated a small focus of Langerhans cell histiocytosis. This is thought to be the first recorded case of Langerhans cell histiocytosis occurring in a sequential discordant lymphoma. Its importance is discussed.

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Figures

Figure 1
Figure 1
The Hodgkin lymphoma. (A) Reed-Sternberg and Hodgkin cells positive for (B) CD15 and (C) CD30 immunostaining. (D, E) Nodule of Langerhans cells with eosinophils showing central necrosis (haematoxylin and eosin stain). (F) Langerhans cells with strong CD1a expression.
Figure 2
Figure 2
The nasopharyngeal B cell non-Hodgkin lymphoma. (A) CD20 expression and (B) nodules of Langerhans cell histiocytosis (C) with strong CD1a positivity.
See this image and copyright information in PMC

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