doi: 10.1021/ol048302j.
TiCl4-promoted multicomponent reaction: a new entry to functionalized alpha-amino acids
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- PMID: 15624964
- DOI: 10.1021/ol048302j
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TiCl4-promoted multicomponent reaction: a new entry to functionalized alpha-amino acids
Org Lett.
.
Abstract
TiCl(4)-promoted multicomponent reactions involving N-tosyl imino ester, cyclic enol ether, and silane reagents in a single one-pot operation provide functionalized alpha-amino acids with multiple stereogenic centers in good to excellent yields. Cis/trans selectivities with optically active substituted dihydrofurans have been investigated.
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