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. 2005 Jan 6;7(1):7-10.
doi: 10.1021/ol048302j.

TiCl4-promoted multicomponent reaction: a new entry to functionalized alpha-amino acids

Arun K Ghosh  1 , Chun-Xiao Xu, Sarang S Kulkarni, Donald Wink
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TiCl4-promoted multicomponent reaction: a new entry to functionalized alpha-amino acids

Arun K Ghosh et al. Org Lett. .

Abstract

TiCl(4)-promoted multicomponent reactions involving N-tosyl imino ester, cyclic enol ether, and silane reagents in a single one-pot operation provide functionalized alpha-amino acids with multiple stereogenic centers in good to excellent yields. Cis/trans selectivities with optically active substituted dihydrofurans have been investigated.

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