doi: 10.1021/ol0477529.
Convergent approach to (E)-alkene and cyclopropane peptide isosteres
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- PMID: 15624988
- DOI: 10.1021/ol0477529
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Convergent approach to (E)-alkene and cyclopropane peptide isosteres
Org Lett.
.
Abstract
Trisubstituted (E)-alkene isosteres (TEADIs) and novel cyclopropane amide bond isosteres (CPDIs) were synthesized by aldimine addition and three-component aldimine addition-cyclopropanation methodologies, respectively. These new peptide mimetics can serve as beta-turn promoters.
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