Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Jan 15;24(2):591-5.
doi: 10.1016/j.neuroimage.2004.09.034. Epub 2004 Nov 18.

Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study

Alexander Gerhard  1 , Johannes Schwarz, Ralph Myers, Richard Wise, Richard B Banati
Affiliations

Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study

Alexander Gerhard et al. Neuroimage. .

Abstract

We obtained [11C](R)-PK11195 PET scans in six patients at different time points between 3 and 150 days after onset of ischemic stroke in order to measure the time course of microglial activation. Increased [11C](R)-PK11195 binding around the lesion was observed as early as 3 days. Scans at later time points showed ongoing changes in the distribution of the [11C](R)-PK11195 signal, involving the area of the primary lesion and areas distant from the primary lesion site. Our data suggest that [11C](R)-PK11195 PET can be used to investigate both the primary lesion and remote pathological changes following Wallerian degeneration.

PubMed Disclaimer

Publication types

LinkOut - more resources