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. 2004;21(1-4):175-8.
doi: 10.1002/biof.552210136.

Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin

Toshiyuki Murakami  1 , Masazumi Miyakoshi, Daisuke Araho, Kenji Mizutani, Toshimitsu Kambara, Takao Ikeda, Wen-Hua Chou, Mihoko Inukai, Asako Takenaka, Kiharu Igarashi
Affiliations

Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin

Toshiyuki Murakami et al. Biofactors. 2004.

Abstract

Hepatoprotective effect of the leaves and stems of Ampelopsis grossedentata together with its main constituent, ampelopsin, were examined on D-galactosamine induced liver injury in rats. The diet containing 50% ethanolic extract (1%) and ampelopsin (0.1%) markedly suppressed the increase of LDH, ALT, AST, alpha-tocopherol levels and GSG/GSSH caused by GalN treatment. These results suggested that ampelopsin from Tocha acted to prevent the oxidative stress in vivo that may have been due to active oxygen species formed by a macrophage by the action of GalN.

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