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. 1992 Apr;88(1):174-80.
doi: 10.1111/j.1365-2249.1992.tb03059.x.

Localization of tumour necrosis factor production in cells at the materno/fetal interface in human pregnancy

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Localization of tumour necrosis factor production in cells at the materno/fetal interface in human pregnancy

G Vince et al. Clin Exp Immunol. 1992 Apr.

Abstract

Biologically active tumour necrosis factor (TNF) was detected in medium conditioned by incubation with explants of human pregnancy decidua or fetal chorionic villous tissue, taken in the first trimester and at term. Addition of endotoxin increased TNF release in most cases. ELISA assays gave similar results for TNF-alpha and also demonstrated low levels of TNF-beta. Using cell populations purified by flow cytometry, secretion of biologically active TNF was shown to be localized to the macrophages. Cytotrophoblast purified from term amniochorion produced no TNF. Both decidual and chorionic villous tissue at term contained mRNA for TNF-alpha and TNF-beta. TNF-alpha mRNA was confined to decidual macrophages in first trimester tissue, and was not present in chorionic cytotrophoblast. TNF-beta mRNA, in contrast, was detected in both macrophage and non-macrophage populations in term decidua.

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References

    1. Immunology. 1988 Sep;65(1):129-34 - PubMed
    1. Clin Obstet Gynecol. 1988 Sep;31(3):553-84 - PubMed
    1. Am J Reprod Immunol Microbiol. 1988 Mar;16(3):123-32 - PubMed
    1. Lab Invest. 1988 Jan;58(1):48-52 - PubMed
    1. J Exp Med. 1988 Aug 1;168(2):789-94 - PubMed

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