Review
[Human parathyroid hormone (1-34) as a new therapeutic agent for osteoporosis]
[Article in
Japanese]
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- PMID: 15632468
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Review
[Human parathyroid hormone (1-34) as a new therapeutic agent for osteoporosis]
[Article in
Japanese]
Clin Calcium.
2005 Jan.
Abstract
Human parathyroid hormone (PTH) is used clinically for severe osteoporosis in North America and Europe. The clinical trial is now in progress in Japan. In this review, I introduce the additive effects of PTH with bone resorption inhibitors, the different effects on bone structure and quality between PTH and bone resorption inhibitor, and the bone-increasing effects of PTH involved in IGF/IRS, AP-1 and Wnt pathways. I focus on new topics including the presentations in ASBMR (American Society for Bone and Mineral Research) 2004.
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