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. 2005 Feb 1;191(3):382-6.
doi: 10.1086/426457. Epub 2004 Dec 23.

Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis

Malcolm G Semple  1 , Angela Cowell, Winfred Dove, Julie Greensill, Paul S McNamara, Claire Halfhide, Paul Shears, Rosalind L Smyth, C Anthony Hart
Affiliations

Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis

Malcolm G Semple et al. J Infect Dis. .

Abstract

The association between severe bronchiolitis and dual infection by human metapneumovirus (hMPV) and human respiratory syncytial virus (hRSV) was investigated in <2-year-old infants with bronchiolitis who were admitted to the hospital during the 2001-2002 winter season. hMPV in nasopharyngeal aspirate and/or cells and fluid collected by nonbronchoscopic bronchoalveolar lavage was detected by reverse transcriptase-polymerase chain reaction (RT-PCR). hRSV was detected in nasopharyngeal aspirate and/or cells and fluid collected by nonbronchoscopic bronchoalveolar lavage by enzyme immunoassay, tissue culture, and RT-PCR. Dual infection with hMPV and hRSV confers a 10-fold increase in relative risk (RR) of admission to a pediatric intensive-care unit for mechanical ventilation (RR, 10.99 [95% confidence interval, 5.0-24.12]; P<.001, by Fisher exact test). Dual infection by hMPV and hRSV is associated with severe bronchiolitis.

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Figures

Table 1.
Table 1.
Site of the hospital stay of infants with bronchiolitis, cross-tabulated with virus detected.
Table 2.
Table 2.
Severity of disease in infants with bronchiolitis, cross-tabulated with virus detected.
Table 3.
Table 3.
Infants receiving mechanical ventilation for severe bronchiolitis, crosstabulated by gestation status at birth and virus detected.
See this image and copyright information in PMC

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