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. 2005 Jan 15;174(2):614-8.
doi: 10.4049/jimmunol.174.2.614.

Cutting edge: MHC class II-restricted killing in vivo during viral infection

Evan R Jellison  1 , Sung-Kwon Kim, Raymond M Welsh
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Cutting edge: MHC class II-restricted killing in vivo during viral infection

Evan R Jellison et al. J Immunol. .

Abstract

Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets.

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