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Clinical Trial
. 2005 Jan;43(1):484-7.
doi: 10.1128/JCM.43.1.484-487.2005.

Polymorphism of the human immunodeficiency virus type 2 (HIV-2) protease gene and selection of drug resistance mutations in HIV-2-infected patients treated with protease inhibitors

F Damond  1 , F Brun-Vezinet, S Matheron, G Peytavin, P Campa, S Pueyo, F Mammano, S Lastere, I Farfara, F Simon, G Chene, D Descamps
Affiliations
Clinical Trial

Polymorphism of the human immunodeficiency virus type 2 (HIV-2) protease gene and selection of drug resistance mutations in HIV-2-infected patients treated with protease inhibitors

F Damond et al. J Clin Microbiol. 2005 Jan.

Abstract

We described the baseline polymorphism of the human immunodeficiency virus type 2 (HIV-2) protease gene from 94 treatment-naive patients and the longitudinal follow-up of 17 protease inhibitor-treated patients. Compared to the HIV-2 consensus sequences, baseline polymorphism involved 47 positions. Substitutions selected under treatment were observed at positions corresponding to HIV-1 resistance mutations as well as at positions of currently unknown impact on HIV-1.

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