Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2005 Jan;43(1):523-5.
doi: 10.1128/JCM.43.1.523-525.2005.

Multiplex PCR-identified cutaneous tuberculosis evoked by Mycobacterium bovis BCG vaccination in a healthy baby

Tatsuma Okazaki  1 , Satoru Ebihara, Hidenori Takahashi, Masanori Asada, Akimasa Sato, Masaaki Seki, Hideyasu Ohto, Hidetada Sasaki
Affiliations
Case Reports

Multiplex PCR-identified cutaneous tuberculosis evoked by Mycobacterium bovis BCG vaccination in a healthy baby

Tatsuma Okazaki et al. J Clin Microbiol. 2005 Jan.

Abstract

This is the first identified case of Mycobacterium bovis bacillus Calmette-Guerin (BCG)-derived cutaneous tuberculosis that localizes at a place different from the vaccination site in hosts without immune deficiency. A healthy baby with a developing abscess is described. A multiplex PCR identified the abscess as originating from M. bovis BCG Tokyo 172.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Agarose gel electrophoresis of the multiplex PCR products. PCR products of M. bovis BCG Tokyo 172 and the colony showed similar bands.
FIG. 2.
FIG. 2.
BCG-derived cutaneous tuberculosis. Interruption of isoniazid treatment resulted in renewed swelling of the abscess. Arrow indicates the abscess. Arrowheads indicate a BCG vaccination scar.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Bedwell, J., S. K. Kairo, M. A. Behr, and J. A. Bygraves. 2001. Identification of substrains of BCG vaccine using multiplex PCR. Vaccine 19:2146-2151. - PubMed
    1. Behr, M. A., M. A. Wilson, W. P. Gill, H. Salamon, G. K. Schoolnik, S. Rane, and P. M. Small. 1999. Comparative genomics of BCG vaccines by whole-genome DNA microarray. Science 284:1520-1523. - PubMed
    1. Cousins, D. V., R. Bastida, A. Cataldi, V. Quse, S. Redrobe, S. Dow, P. Dulgnan, A. Murray, C. Dupont, N. Ahmed, D. M. Collins, W. R. Butler, D. Dawson, D. Rodriguez, J. Loureiro, M. I. Romano, A. Alito, M. Zumarraga, and A. Bernardelli. 2003. Tuberculosis in seals caused by a novel member of the Mycobacterium tuberculosis complex: Mycobacterium pinnipedii sp. nov. Int. J. Syst. Evol. Microbiol. 53:1305-1314. - PubMed
    1. Lamm, D. L., V. D. Stogdill, B. J. Stogdill, and R. G. Crispen. 1986. Complications of bacillus Calmette-Guérin immunotherapy in 1,278 patients with bladder cancer. J. Urol. 135:272-274. - PubMed
    1. Magdalena, J., P. Supply, and C. Locht. 1998. Specific differentiation between Mycobacterium bovis BCG and virulent strains of the Mycobacterium tuberculosis complex. J. Clin. Microbiol. 36:2471-2476. - PMC - PubMed

Publication types