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. 2005 Jan;69(1):124-6.
doi: 10.1253/circj.69.124.

Effects of salt loading on blood pressure in mice lacking the prostanoid receptor gene

Hidetsuna Watanabe  1 , Tetsuo Katoh, Masaaki Eiro, Masaya Iwamoto, Fumitaka Ushikubi, Shuh Narumiya, Tsuyoshi Watanabe
Affiliations
Free article

Effects of salt loading on blood pressure in mice lacking the prostanoid receptor gene

Hidetsuna Watanabe et al. Circ J. 2005 Jan.
Free article

Abstract

Background: This study examined whether targeted disruption of the genes for the prostacyclin receptor (IP) or the thromboxane A2 receptor (TP) confers a susceptibility to salt-dependent hypertension.

Methods and results: Eight female IP- or TP-deficient mice were examined. Baseline systolic blood pressure (SBP) did not differ between TP(-/-) and TP(+/+), but was significantly lower in the IP(-/-) group than in the IP(+/+). With a high salt diet, SBP in IP(-/-) gradually increased. In contrast, SBP in the IP(+/+), TP(-/-), or TP(+/+) groups remained unchanged.

Conclusions: The prostacyclin receptor may participate in the maintenance of baseline BP. With salt loading, BP adaptation may take place, at least in part, via IP mediated signals.

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