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Review
. 2005 Jan;81(951):1-6.
doi: 10.1136/pgmj.2004.020511.

Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes

M E Tushuizen  1 , M Diamant, R J Heine
Affiliations
Review

Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes

M E Tushuizen et al. Postgrad Med J. 2005 Jan.

Abstract

The worldwide prevalence of type 2 diabetes mellitus has reached epidemic proportions. The so-called traditional risk factors cannot fully explain the excessive cardiovascular disease risk of type 2 diabetic patients. Numerous studies indicate that postprandial metabolic derangements, most notably hyperglycaemia and hypertriglyceridaemia, which are exaggerated and prolonged in type 2 diabetes, are important cardiovascular disease risk factors since they induce oxidative stress and endothelial dysfunctions. This review discusses the current evidence showing that postprandial dysmetabolism may indeed constitute an important cardiovascular disease risk factor as well as the mechanisms underlying this association. Finally, some possible therapeutic options and recommendations for future research are discussed.

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