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. 2004 Jun;48(3):406-13.
doi: 10.1590/s0004-27302004000300013. Epub 2004 Aug 26.

[Growth or somatotrophic hormone: new perspectives in isolated GH deficiency after description of the mutation in the GHRH receptor gene in individuals of Itabaianinha County, Brazil]

[Article in Portuguese]
Anita Hermínia O Souza  1 , Roberto Salvatori, Carlos E Martinelli Jr, Walter M O Carvalho, Carlos A Menezes, Elenilde S de A Barretto, José A S Barreto Filho, Marta R S de Alcântara, Carla R P Oliveira, Paula R S de Alcântara, Roberto J R Ramalho, Hélio A Oliveira, Ivana B de Lima, Jamille N Carneiro, Marcos M Santos, Matthew S Gill, Peter E Clayton, Manuel H A Oliveira
Affiliations

[Growth or somatotrophic hormone: new perspectives in isolated GH deficiency after description of the mutation in the GHRH receptor gene in individuals of Itabaianinha County, Brazil]

[Article in Portuguese]
Anita Hermínia O Souza et al. Arq Bras Endocrinol Metabol. 2004 Jun.

Abstract

In addition to stimulating body growth, growth or somatotrophic hormone plays an important role in metabolism, body composition, lipid profile, cardiovascular status and longevity. Its control is multiregulated by hormones, metabolites and hypothalamic peptides. Obtained data of the isolated growth hormone deficiency (IGHD) after the description of the IVS1+1G-->A GHRH receptor gene mutation in individuals of Itabaianinha County are reviewed. New perspectives about the growth hormone resistance model, the importance of GHRH in the control of GH secretion, the frequency of GHRH-R gene mutations, the diagnostic relevance of IGF-I and the metabolic, cardiovascular and quality of life findings are approached.

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