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. 2005;6(1):R8.
doi: 10.1186/gb-2004-6-1-r8. Epub 2004 Dec 20.

Using ontologies to describe mouse phenotypes

Georgios V Gkoutos  1 , Eain C J Green, Ann-Marie Mallon, John M Hancock, Duncan Davidson
Affiliations

Using ontologies to describe mouse phenotypes

Georgios V Gkoutos et al. Genome Biol. 2005.

Abstract

The mouse is an important model of human genetic disease. Describing phenotypes of mutant mice in a standard, structured manner that will facilitate data mining is a major challenge for bioinformatics. Here we describe a novel, compositional approach to this problem which combines core ontologies from a variety of sources. This produces a framework with greater flexibility, power and economy than previous approaches. We discuss some of the issues this approach raises.

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Figures

Figure 1
Figure 1
Proposed schema for constructing phenotype ontologies (modified from [13]).
Figure 2
Figure 2
Schematic of phenotype description as the sum of the results of assaying different characters. PC, phenotypic character.
Figure 3
Figure 3
Two snapshots of the ontology visualized using DAG-edit.
Figure 4
Figure 4
A snapshot of the ontology using Protégé-2000.
See this image and copyright information in PMC

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