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Review
. 2005;7(1):33-6.
doi: 10.1186/bcr972. Epub 2004 Nov 25.

New highlights on stroma-epithelial interactions in breast cancer

Mary Helen Barcellos-Hoff  1 , Daniel Medina
Affiliations
Review

New highlights on stroma-epithelial interactions in breast cancer

Mary Helen Barcellos-Hoff et al. Breast Cancer Res. 2005.

Abstract

Although the stroma in which carcinomas arise has been previously regarded as a bystander to the clonal expansion and acquisition of malignant characteristics of tumor cells, it is now generally acknowledged that stromal changes are required for the establishment of cancer. In the present article, we discuss three recent publications that highlight the complex role the stroma has during the development of cancer and the potential for targeting the stroma by therapeutic approaches.

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References

    1. Bissell MJ, Barcellos-Hoff MH. The influence of extracellular matrix on gene expression: is structure the message? J Cell Sci. 1987;8:327–343. - PubMed
    1. Decosse JJ, Gossens CL, Kuzma JF, Unsworth D. Breast cancer: induction of differentiation by embryonic tissue. Science. 1973;181:1057–1058. - PubMed
    1. Cooper M, Pinkus H. Intrauterine transplantation of rat basal cell carcinoma as a model for reconversion of malignant to benign growth. Cancer Res. 1977;37:2544–2552. - PubMed
    1. Fujii H, Cunha GR, Norman JT. The induction of adenocarinomatous differentiation in neoplastic bladder epithelium by an embryonic prostatic inducer. J Urol. 1982;128:858–861. - PubMed
    1. Kamiya K, Yasukawa-Barnes J, Mitchen JM, Gould MN, Clifton KH. Evidence that carcinogenesis involves an imbalance between epigenetic high-frequency initiation and suppression of promotion. Proc Natl Acad Sci USA. 1995;92:1332–1336. - PMC - PubMed

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