Review
doi: 10.1186/bcr972.
Epub 2004 Nov 25.
New highlights on stroma-epithelial interactions in breast cancer
Affiliations
- PMID: 15642180
- PMCID: PMC1064117
- DOI: 10.1186/bcr972
Item in Clipboard
Review
New highlights on stroma-epithelial interactions in breast cancer
Breast Cancer Res.
2005.
Abstract
Although the stroma in which carcinomas arise has been previously regarded as a bystander to the clonal expansion and acquisition of malignant characteristics of tumor cells, it is now generally acknowledged that stromal changes are required for the establishment of cancer. In the present article, we discuss three recent publications that highlight the complex role the stroma has during the development of cancer and the potential for targeting the stroma by therapeutic approaches.
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