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. 1992 Mar;17(2):317-23.
doi: 10.1016/0363-5023(92)90414-k.

Platelet-derived growth factor in Dupuytren's disease

M A Badalamente  1 , L C Hurst, S K Grandia, S P Sampson
Affiliations

Platelet-derived growth factor in Dupuytren's disease

M A Badalamente et al. J Hand Surg Am. 1992 Mar.

Abstract

This study investigated whether platelet-derived growth factor, a potent inducer of cell proliferation, was identifiable in association with myofibroblasts in Dupuytren's disease. Myofibroblasts in the hypercellular disease stages showed a strong reaction to platelet-derived growth factor antibody using light and electron microscopic immunochemical labels. Platelet-derived growth factor may play a role as a cellular signal for myofibroblast proliferation in the formation of the pathognomonic nodule in Dupuytren's disease.

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