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. 2005 Jan 11;64(1):129-31.
doi: 10.1212/01.WNL.0000148590.39911.DF.

Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

E Masliah  1 , L Hansen, A Adame, L Crews, F Bard, C Lee, P Seubert, D Games, L Kirby, D Schenk
Affiliations

Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

E Masliah et al. Neurology. .

Abstract

The authors report a patient with Alzheimer disease (AD) without encephalitis who was immunized with AN-1792 (an adjuvanted formulation of Abeta-42). There were no amyloid plaques in the frontal cortex and abundant Abeta-immunoreactive macrophages, but tangles and amyloid angiopathy were present. The white matter appeared normal and minimal lymphocytic infiltration in the leptomeninges was observed. This case illustrates the effects of an Abeta-based immunization on AD pathogenesis in the absence of overt meningoencephalitis and leukoencephalopathy.

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Comment in

  • Immunization therapy for Alzheimer disease?
    Bennett DA, Holtzman DM. Bennett DA, et al. Neurology. 2005 Jan 11;64(1):10-2. doi: 10.1212/01.WNL.0000150527.24596.29. Neurology. 2005. PMID: 15642896 Review. No abstract available.

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