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. 2005 Jan 11;64(1):132-3.
doi: 10.1212/01.WNL.0000148591.63727.80.

Absence of cholinergic deficits in "pure" vascular dementia

E Perry  1 , I Ziabreva, R Perry, D Aarsland, C Ballard
Affiliations

Absence of cholinergic deficits in "pure" vascular dementia

E Perry et al. Neurology. .

Abstract

Choline acetyltransferase in temporal cortex was evaluated as a marker of cholinergic function in autopsied dementia cases (9 vascular dementia [VaD] cases, 12 "mixed" VaD and Alzheimer disease [AD] cases, 10 AD cases, 12 control subjects). Patients with AD (t = 2.5, p = 0.02) and "mixed" VaD and AD (t = 3.8, p = 0.001) had greater cholinergic deficits than age-matched control subjects and patients with "pure" VaD. The absence of cholinergic deficits in "pure" VaD may be relevant to the pharmacologic treatment of these patients.

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