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Review
. 2005 Mar;32(1):97-103, ix.
doi: 10.1016/j.ogc.2004.10.003.

Invasive genetic diagnosis in multiple pregnancies

Zvi Appelman  1 , Boris Furman
Affiliations
Review

Invasive genetic diagnosis in multiple pregnancies

Zvi Appelman et al. Obstet Gynecol Clin North Am. 2005 Mar.

Abstract

Chromosomal anomalies and mendelian diseases are more frequent in multiple gestations than in singletons. Prenatal diagnosis is recommended in multiple pregnancies whenever indicated. Invasive testing using amniocentesis or chorionic villus sampling can be performed safely. Chorionic villus sampling has a significant advantage over amniocentesis because it offers rapid karyotyping and biochemical and DNA studies at an early stage of pregnancy. Only experienced centers should perform these procedures because of the technical aspects and the expertise needed in handling discordant results.

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